Family Nurse Practitioner Exam

Erythromycin combined with sulfisoxazole is contraindicated in which condition?

1. G6PD deficiency anemia

2. Lead poisoning

3. Beta thalassemia minor

4. B12 deficiency anemia

The correct answer is: G6PD deficiency anemia

Erythromycin combined with sulfisoxazole is contraindicated in individuals with G6PD deficiency anemia due to the risk of hemolytic anemia. G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency is a genetic disorder that affects red blood cell integrity and their ability to withstand oxidative stress. Both erythromycin and sulfisoxazole can provoke oxidative stress in these patients, leading to the breakdown of red blood cells and subsequent hemolysis. In the context of other conditions: - Lead poisoning is not specifically exacerbated by erythromycin and sulfisoxazole. The management of lead poisoning typically focuses on chelation therapy rather than avoiding specific antibiotics. - Beta thalassemia minor is a mild form of thalassemia, and while patients may have anemia, they do not experience the same oxidative stress issues as those with G6PD deficiency; thus, the combination would not be contraindicated. - B12 deficiency anemia results from a lack of vitamin B12, which can lead to megaloblastic anemia. This condition is not associated with the oxidative stress risks posed by the medications in question, and therefore the combination is not contraindicated. Overall, the specific risk of hemolytic anemia in G