Family Nurse Practitioner Exam

What is the typical consequence of starting aspirin therapy for cardiovascular protection?

1. Increased platelet count

2. Irreversible inhibition of platelet aggregation

3. Higher risk of bleeding disorders

4. Normalized blood pressure levels

The correct answer is: Irreversible inhibition of platelet aggregation

The typical consequence of starting aspirin therapy for cardiovascular protection is the irreversible inhibition of platelet aggregation. Aspirin works by irreversibly acetylating the cyclooxygenase-1 (COX-1) enzyme in platelets, which leads to a decrease in the synthesis of thromboxane A2—a powerful promoter of platelet aggregation. This action diminishes the platelets' ability to clump together, thereby reducing the risk of thrombus formation in the arteries, which is particularly beneficial for preventing events such as heart attacks or strokes. While increased platelet count, a higher risk of bleeding disorders, and normalized blood pressure levels can be associated with various conditions or treatments, they are not direct results of aspirin therapy in this context. The purpose of aspirin in cardiovascular protection is specifically related to its impact on platelet function rather than affecting platelet count or managing blood pressure directly. Therefore, the key aspect of its action is its irreversible effect on platelet aggregation, making it a crucial medication in cardiovascular prevention strategies.