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Which of the following is not a benign physiologic variant?

  1. Internal tibial torsion

  2. Supernumerary nipples

  3. Split uvula

  4. Cheilosis

The correct answer is: Cheilosis

Cheilosis, also known as angular cheilitis, is characterized by inflammation and cracking at the corners of the mouth and is typically associated with nutritional deficiencies, such as vitamin B2 (riboflavin) or iron deficiency, rather than being a benign physiologic variant. It often signals a pathological condition rather than a normal anatomical variation. In contrast, internal tibial torsion, supernumerary nipples, and split uvula are all considered benign physiological variants. Internal tibial torsion involves a twisting of the tibia and is common in children, often resolving without intervention as the child grows. Supernumerary nipples, or additional breast tissue, can appear along the milk line but do not generally cause health issues. A split uvula, which involves a bifid appearance, is a congenital condition and is not typically associated with any pathological consequences. These variations are typically benign and do not indicate underlying health problems, distinguishing them from cheilosis.