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Which type of testing is essential before prescribing hydroxychloroquine?

  1. Liver function tests

  2. CBC

  3. Blood glucose testing

  4. Comprehensive eye exam

The correct answer is: Comprehensive eye exam

Before prescribing hydroxychloroquine, it is essential to conduct a comprehensive eye exam due to the potential for ocular toxicity associated with the medication. Hydroxychloroquine can lead to retinal damage, which may become irreversible if not monitored appropriately. Regular eye exams are critical for patients on hydroxychloroquine, especially because the risk of retinal toxicity increases with higher cumulative doses and longer treatment duration. By performing a thorough eye examination prior to initiating therapy, healthcare providers can establish a baseline for the patient's vision and provide necessary monitoring throughout treatment, ensuring early detection of any adverse effects. While other tests like liver function tests or a complete blood count may be relevant for assessing other conditions or potential drug interactions, they do not specifically address the unique ocular risks posed by hydroxychloroquine. Blood glucose testing is also not directly related, as hydroxychloroquine is not associated with glucose metabolism or diabetes management. Thus, the comprehensive eye exam stands out as the most pertinent and necessary evaluation prior to prescribing hydroxychloroquine.